Key result
Delayed electric shocks delivered to the skin during early cardiac systole significantly attenuated mean arterial pressure increases compared with ECG R-wave synchronous shocks, and elicited differential neural responses in the amygdala, insula, and pons.
Why the study?
Does the timing of somatosensory stimuli relative to the cardiac cycle alter central neural activity and blood pressure responses in healthy adults?
Population
11 healthy right-handed adults with no history of psychiatric, neurological or cardiovascular illness or…
Comparison
Electrocutaneous shock delivered to the dorsum… vs Electrocutaneous shock delivered synchronous…
Design
Other, pseudorandomized presentation
Authors
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Should not change practice; hypothesis-generating for cardiac-gated autonomic modulation pending clinical validation.
Does the timing of somatosensory stimuli relative to the cardiac cycle alter central neural activity and blood pressure responses in healthy adults?
p-value: p=0.001
Somatosensory stimuli delivered during early cardiac systole inhibit blood pressure increases and evoke differential neural activity in the amygdala, insula, and pons compared to stimuli delivered at the R-wave.
Gray et al. (2009) studied Healthy adults (n=11). ECG R-wave delayed electrical skin shocks vs. ECG R-wave synchronous electrical skin shocks was evaluated on Mean arterial pressure (MAP) response (p=0.001). Delayed electric shocks delivered to the skin during early cardiac systole significantly attenuated mean arterial pressure increases compared with ECG R-wave synchronous shocks, and elicited differential neural responses in the amygdala, insula, and pons.
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