Why the study?
What is the clinical role of troponin, lactate, and B-type natriuretic peptide in the assessment and management of children with critical cardiac disease?
What is the clinical role of troponin, lactate, and B-type natriuretic peptide in the assessment and management of children with critical cardiac disease?
In pediatric cardiac critical care, monitoring the trends of biomarkers such as lactate, troponin, and BNP provides more valuable clinical information than single isolated measurements.
Supports serial biomarker monitoring in pediatric cardiac critical care; leaves open need for prospective validation studies.
OBJECTIVES: In this review, we discuss the physiology, pathophysiology, and clinical role of troponin, lactate, and B-type natriuretic peptide in the assessment and management of children with critical cardiac disease. DATA SOURCE: MEDLINE, PubMed. CONCLUSION: Lactate, troponin, and B-type natriuretic peptide continue to be valuable biomarkers in the assessment and management of critically ill children with cardiac disease. However, the use of these markers as a single measurement is handicapped by the wide variety of clinical scenarios in which they may be increased. The overall trend may be more useful than any single level with a persistent or rising value of more importance than an elevated initial value.
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Domico et al. (2016) conducted a review in Critical cardiac disease. Biomarkers (troponin, lactate, and B-type natriuretic peptide) was evaluated.
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