Key result
Cardiac biomarkers including troponin, BNP, and CRP increasingly aid acute cardiac disease diagnosis and treatment.
Why the study?
Biomarker use is rapidly expanding in cardiac disease, raising the risk of excessive enthusiasm without circumspect evaluation of data guiding their clinical use.
This review provides an overview of the clinical application, interpretation, and knowledge gaps associated with cardiac biomarkers such as troponin, BNP, and CRP in acute cardiac disease.
Answers are grounded in this paper and cite their sources.
Cautious use of novel biomarkers is warranted in practice; leaves open rigorous outcome validation before routine adoption.
The use of biomarkers to aid diagnosis and treatment is increasing rapidly as genomics and proteomics help us expand the number of markers we can use and as an improved understanding of the pathophysiology of cardiac disease guides their use. However, as with all rapidly expanding fields, there is the risk of excessive enthusiasm unless we are circumspect about the data that guide the clinical use of these new tools. This review focuses first on how to use troponin, which at present is the best validated of the new markers, and will hopefully provide insight into how to use this biomarker more productively by distinguishing subsets of patients and by providing an understanding of the meaning of elevations in various clinical situations. The review then discusses the use as well as the knowledge gaps associated with emerging biomarkers such as B-type natriuretic peptide and C-reactive protein, which are increasingly moving toward more productive clinical use. Finally, it reflects on some of the large number of markers that are still in development.
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Jaffe et al. (2006) conducted a review in Acute Cardiac Disease. Cardiac biomarkers (troponin, B-type natriuretic peptide, C-reactive protein) was evaluated. Cardiac biomarkers, including troponin, B-type natriuretic peptide, and C-reactive protein, are increasingly utilized to aid diagnosis and treatment in acute cardiac disease.
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