Why the study?
Does cAMP regulate myosin ATPase activity in the maturing rat heart?
Population
Maturing rat heart (ventricles)
Comparison
Addition of adenosine-3',5'-cyclic monophosphate vs Absence of cAMP
Design
Preclinical
Authors
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Findings in rat models warrant no clinical translation; leaves open cAMP regulation of myosin ATPase during human cardiac maturation.
Does cAMP regulate myosin ATPase activity in the maturing rat heart?
This study demonstrates that cAMP regulates V1 myosin ATPase activity in an age-dependent manner in the maturing rat heart.
Horowits et al. (1987) studied this question.
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