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October 1, 1981Circulation ResearchOpen Access

Isomyosin distribution in normal and pressure-overloaded rat ventricular myocardium. An immunohistochemical study.

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Population

Normal and renal hypertensive rats across different developmental stages (newborn, 1-month-old, and adult).

Comparison

Pressure overload induced by renal hypertension… vs Normal rats without induced hypertension.

Design

Preclinical

Follow-up

2 months after surgery

Authors

LGLuisa GorzaHôpital FochPPP. PaulettoUniversidade Estadual do Oeste do ParanáAPAchille C. PessinaGeneral / Preventive / Lipids

Discussion

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Implication

Supports load-dependent myosin regulation in rodent models; leaves open translation to human disease.

Structured PICO

P
Population
Normal and renal hypertensive rats across different developmental stages (newborn, 1-month-old, and adult).
I
Intervention
Pressure overload induced by renal hypertension surgery.
C
Comparator
Normal rats without induced hypertension.
O
Outcome
Distribution of specific isomyosin in the ventricular myocardium assessed by immunofluorescent staining.surrogate

Pressure overload from systemic hypertension induces a complete transformation of ventricular isomyosin distribution in rats, suggesting a load-dependent regulation of myosin heavy chain expression.

Cite This Study

Gorza et al. (1981) studied this question.

synapsesocial.com/papers/6a83d1bdfd07e211f9fe1e36https://doi.org/10.1161/01.res.49.4.1003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Contractile State of Cardiac Muscle Obtained from Cats with Experimentally Produced Ventricular Hypertrophy and Heart Failure1967 · 501 citations
  2. 2Myosin types in cultured muscle cells.1980 · 56 citations
  3. 3Structural differences in the heavy chains of rat ventricular myosin isoenzymes1979 · 225 citations
  4. 4ATPase Activity of Myosin Correlated with Speed of Muscle Shortening1967 · 1,986 citations
  5. 5Myosin types and fiber types in cardiac muscle. I. Ventricular myocardium.1981 · 131 citations