Key result
Pressure overload-induced cardiac hypertrophy in rats significantly increased V3 myosin expression, which was higher in the subendocardial versus subepicardial myocardium at 8 weeks (46.6% vs 36.2%).
Population
Young male rats (25-day-old)
Comparison
Ascending aorta constriction to induce… vs Subepicardial myocardium (internal comparison)
Design
Preclinical
Follow-up
8 weeks
Authors
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Hypothesis-generating for regional myosin shifts in hypertrophy; leaves open translation to human disease.
Absolute Event Rate: 46.6% vs 36.2%
p-value: p=≤0.05
In a rat model of pressure overload-induced cardiac hypertrophy, V3 myosin expression increases significantly more in the subendocardial myocardium compared to the subepicardial myocardium.
Bugaisky et al. (1990) studied Cardiac hypertrophy and congestive heart failure. Ascending aorta constriction (pressure overload) vs. Subepicardial myocardium (regional comparison) was evaluated on Myosin V3 isoform expression percentage (p=≤0.05). Pressure overload-induced cardiac hypertrophy in rats significantly increased V3 myosin expression, which was higher in the subendocardial versus subepicardial myocardium at 8 weeks (46.6% vs 36.2%).
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