October 1, 1986Circulation Research
Myosin isoenzymes of vascular smooth and cardiac muscle in the spontaneously hypertensive and normotensive male and female rat: a comparative study.
Why the study?
Does spontaneous hypertension alter ventricular isomyosin patterns and myofibrillar ATPase activity differently in male and female rats?
Population
Adult spontaneously hypertensive (H) rats and normotensive (N) controls of both sexes
Comparison
Spontaneous hypertension vs Normotensive controls
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Sex differences in rat myosin shifts are hypothesis-generating; human studies needed before clinical translation.
Structured PICO
Does spontaneous hypertension alter ventricular isomyosin patterns and myofibrillar ATPase activity differently in male and female rats?
P
Population
Adult spontaneously hypertensive (H) rats and normotensive (N) controls of both sexes
I
Intervention
Spontaneous hypertension
C
Comparator
Normotensive controls
O
Outcome
Ventricular isomyosin pattern and myofibrillar ATPase activitysurrogate
Spontaneous hypertension induces a shift in ventricular isomyosin patterns and decreases myofibrillar ATPase activity in rats, with significant sex-based differences in these biochemical adaptations.
Cite This Study
Morano et al. (1986) studied this question.