December 2, 1984European Heart Journal

Isomyosins, microtubules and desmin during the onset of cardiac hypertrophy in the rat

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Population

Young rats with aortic stenosis or adult rats with aortic insufficiency

Design

Preclinical

Authors

LRL. RappaportBoston Children's Hospital JSJane‐Lise SamuelUniversité Paris Cité BBBénédicte BertierInserm

Discussion

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Implication

Early cytoskeletal shifts in rat hypertrophy models; hypothesis-generating for human compensatory mechanisms, pending translational studies.

Structured PICO

Population

Young rats with aortic stenosis or adult rats with aortic insufficiency

Intervention

Chronic overloading of the rat heart via aortic stenosis or aortic insufficiency

Outcome

Timing and location of the shift in expression of isomyosins within myocytes, and changes in the pattern of intermediate filaments of desmin and/or microtubulessurrogate

Chronic cardiac overload in rats induces early cytoskeletal adaptations, including a shift in isomyosin expression and microtubule reorganization, which may trigger compensatory hypertrophy.

Cite This Study

Rappaport et al. (1984) studied this question.

synapsesocial.com/papers/6a736c468412e8bdfca72828 https://doi.org/10.1093/eurheartj/5.suppl_f.243

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Implication

Early cytoskeletal shifts in rat hypertrophy models; hypothesis-generating for human compensatory mechanisms, pending translational studies.

Isomyosins, microtubules and desmin during the onset of cardiac hypertrophy in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Isomyosins, microtubules and desmin during the onset of cardiac hypertrophy in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider