Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 1, 1996AJP Heart and Circulatory Physiology

Role of microtubules in myocyte contractile dysfunction during cardiac hypertrophy in the rat

View Full Paper
Ask AI
Bookmark
Share

Population

Rats with pressure-overload left ventricular (LV) hypertrophy

Comparison

Depolymerization of microtubules vs Untreated hypertrophied myocytes

Design

Preclinical

Authors

YIYuji IshibashiKyushu UniversityHTH TsutsuiKyushu UniversitySYShunsuke YamamotoKyushu University

Discussion

Loading...

Member takes

Implication

Suggests microtubule dynamics as a reversible driver of myocyte dysfunction in pressure overload; hypothesis-generating for human heart failure therapies.

Structured PICO

P
Population
Rats with pressure-overload left ventricular (LV) hypertrophy
I
Intervention
Depolymerization of microtubules
C
Comparator
Untreated hypertrophied myocytes
O
Outcome
Myocyte contractile function and amounts of free and polymerized tubulin proteinssurrogate

The progressive increase in microtubule density during pressure-overload LV hypertrophy causes myocyte contractile dysfunction, which can be reversed by microtubule depolymerization.

Cite This Study

Ishibashi et al. (1996) studied this question.

synapsesocial.com/papers/6a8cee922c3e0995d771b9eahttps://doi.org/10.1152/ajpheart.1996.271.5.h1978
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of microtubules in contractile dysfunction of hypertrophied cardiocytes.1994 · 137 citations
  2. 2Basis for Increased Microtubules in Pressure-Hypertrophied Cardiocytes1996 · 79 citations
  3. 3Cytoskeletal Role in the Transition From Compensated to Decompensated Hypertrophy During Adult Canine Left Ventricular Pressure Overloading1998 · 133 citations
  4. 4Microtubule Stabilization in Pressure Overload Cardiac Hypertrophy1997 · 124 citations
  5. 5Cytoskeletal Role in the Contractile Dysfunction of Hypertrophied Myocardium1993 · 278 citations