Why the study?
Can principal component analysis of the surface ECG detect changes in atrial fibrillation frequency parameters in response to antiarrhythmic drugs?
Population
20 patients with persistent atrial fibrillation
Comparison
Intravenous administration of 1 of 4 drugs… vs Drug-free state
Design
Other
Follow-up
Acute (60 minutes baseline plus post-drug administration)
Authors
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May support noninvasive ECG monitoring of AAD effects in persistent AF; leaves open clinical utility pending prospective validation.
Can principal component analysis of the surface ECG detect changes in atrial fibrillation frequency parameters in response to antiarrhythmic drugs?
Principal component analysis of the surface ECG can successfully extract atrial frequency characteristics and detect electrophysiological changes induced by antiarrhythmic drugs in patients with persistent AF.
RAINE et al. (2004) studied this question.
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