Key result
Spironolactone and its metabolite canrenoic acid blocked HERG channels in a concentration-dependent manner, with spironolactone showing an IC50 of 23.0 micromol/L.
p-value: p=<0.05
Spironolactone and its metabolite canrenoic acid block HERG channels, providing a mechanistic basis for their electrophysiological effects.
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May warrant ECG caution in overdose; hypothesis-generating for clinical arrhythmia risk.
Caballero et al. (2003) studied this question. Spironolactone and canrenoic acid was evaluated on HERG current block (p=<0.05). Spironolactone and its metabolite canrenoic acid blocked HERG channels in a concentration-dependent manner, with spironolactone showing an IC50 of 23.0 micromol/L.
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