Why the study?
Does colestipol/niacin plus diet therapy reduce carotid intima-media thickness in nonsmoking men with prior CABG?
Population
188 nonsmoking men, aged 40 to 59 years, with prior coronary artery bypass graft surgery
Comparison
Colestipol/niacin plus diet therapy vs Placebo plus diet therapy
Design
RCT, randomized
Follow-up
up to 4 years
Authors
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Supports colestipol/niacin plus diet post-CABG; confirms IMT regression as a responsive surrogate in lipid-lowering RCTs.
Does colestipol/niacin plus diet therapy reduce carotid intima-media thickness in nonsmoking men with prior CABG?
Aggressive lipid-lowering therapy with colestipol/niacin significantly reduces carotid intima-media thickness at 1 year in men with prior CABG.
Mack et al. (1993) studied this question.
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