Key result
This article presents the design and rationale for a 2-by-2 factorial randomized trial evaluating interpersonal psychotherapy and citalopram for major depression in patients with coronary artery disease.
Why the study?
Does interpersonal psychotherapy and/or citalopram improve depression symptoms in stable coronary artery disease patients with major depression?
Population
280 stable coronary artery disease patients with a current major depressive episode of at least 4 weeks'…
Comparison
Interpersonal psychotherapy and/or citalopram in… vs Standardized clinical management and/or…
Design
Other, Randomly assigned in a 2-by-2 factorial design, Blinded, centralized…
Follow-up
12 weeks
Authors
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This paper describes the design and rationale of the CREATE trial, which evaluates the efficacy of interpersonal psychotherapy and citalopram for treating major depression in patients with coronary artery disease.
RCT (n=280)
Blinded
2-by-2 factorial
Yes
Does interpersonal psychotherapy and/or citalopram improve depression symptoms in stable coronary artery disease patients with major depression?
This paper describes the design and rationale of the CREATE trial, which evaluates the efficacy of interpersonal psychotherapy and citalopram for treating major depression in patients with coronary artery disease.
Frasure‐Smith et al. (2006) conducted an RCT in Major depression in coronary artery disease (n=280). Interpersonal psychotherapy (IPT) and citalopram vs. Standardized clinical management (CM) and pill-placebo was evaluated on Blinded, centralized, 24-item HAM-D telephone ratings. This article presents the design and rationale for a 2-by-2 factorial randomized trial evaluating interpersonal psychotherapy and citalopram for major depression in patients with coronary artery disease.
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