Asymmetric One-Pot Construction of Three Stereogenic Elements: Chiral Carbon Center, Stereoisomeric Alkenes, and Chirality of Axial Styrenes

An organocatalytic enantioselective method for the synthesis of multiple stereoisomers bearing E, Z configurations, stereogenic carbon centers, and axially chiral styrenes is reported. The method enabled the rapid construction of a series of stereochemical complexity products with excellent E, Z selectivity, diastereoselectivity (>20:1 dr), and enantioselectivity (up to 96% ee). This method provides an efficient and concise synthesis route of multiple stereoisomers with a wide range of potential applications in organic synthesis.