Key result
High-intensity intermittent exercise significantly increased brain-derived neurotrophic factor (BDNF) levels immediately post-exercise compared to baseline (P=0.022) in healthy men.
Why the study?
Does high-intensity intermittent exercise compared to moderate-intensity continuous exercise improve indices of cardio-inflammatory health in physically active men?
RCT (n=12)
Open-label
Randomized crossover
No
Does high-intensity intermittent exercise compared to moderate-intensity continuous exercise improve indices of cardio-inflammatory health in physically active men?
p-value: p=0.022
High-intensity intermittent exercise promotes an increase in BDNF levels compared to moderate-intensity continuous exercise, favoring an anti-atherogenic profile in healthy active men.
May inform exercise for neuroplasticity; leaves open translation to clinical populations or outcomes.
The aim of this study was to evaluate the influence to acute exercises performed in different intensities with volume equalized (5 km) on indices of cardio-inflammatory health. Twelve physically active male subjects (age, 23.22 5.47 years; height, 174.75 5.80 m; weight, 75.13 6.61 kg; maximal oxygen uptake, 52.92 mL/kg/min), after determination of peak oxygen uptake (VO2Peak) and the speed associated with VO2Peak (sVO2Peak), completed two randomly experimental trials: high-intensity intermittent exercise (HIIE: 1:1 at 100% sVO2Peak) and moderate-intensity continuous exercise (MICE: 70% sVO2Peak). Brain-derived neurotrophic factor (BDNF), adiponectin and plasminogen inhibitor-1 (PAI-1) data were analyzed pre, immediately, and 60 min after the exercise session. Statistical analysis comparisons between moments and between HIIE and MICE were performed using a mixed model and statistical and significance was set at < 5%. PAI-1 presented an effect for time from pre to immediately after exercise moment (P< 0.018) and from immediately to 60 min after exercise moment (P< 0.001) only in MICE. BDNF presented an effect for time from pre to immediately after exercise to HIIE (P< 0.022) and from immediately to 60 min after exercise to MICE (P< 0.034). HIIE promotes BDNF increase and that there is negative correlation between PAI-1 concentrations and BDNF in both protocols in healthy sportsmen, favoring an anti-atherogenic profile.
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Santos et al. (2016) conducted an RCT in Healthy physically active (n=12). High-intensity intermittent exercise (HIIE) vs. Moderate-intensity continuous exercise (MICE) at 70% sVO2Peak was evaluated on Brain-derived neurotrophic factor (BDNF) levels (p=0.022). High-intensity intermittent exercise significantly increased brain-derived neurotrophic factor (BDNF) levels immediately post-exercise compared to baseline (P=0.022) in healthy men.
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