Key result
Chronic NMDA administration in Wistar rats prolonged repolarization, induced electrical instability, and facilitated ventricular arrhythmias (P<0.01), which were normalized by MK801 co-treatment.
Why the study?
Does chronic NMDAR activation induce cardiac electrical remodeling and increase susceptibility to ventricular arrhythmias in Wistar rats?
Population
Wistar rats
Comparison
NMDA or NMDA plus MK801 administered for 14 days vs 0.9% saline administered for 14 days
Design
Preclinical, randomly administered
Follow-up
14 days
Authors
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Should not yet alter clinical arrhythmia management; leaves open NMDAR role in human ventricular arrhythmogenesis.
RCT
Randomized
Does chronic NMDAR activation induce cardiac electrical remodeling and increase susceptibility to ventricular arrhythmias in Wistar rats?
p-value: p=<0.01
Chronic NMDAR activation induces cardiac electrical remodeling and increases susceptibility to ventricular arrhythmias in a rat model, suggesting a potential mechanism for arrhythmogenesis.
Shi et al. (2014) conducted an RCT in Ventricular arrhythmias susceptibility. NMDA vs. 0.9% saline or NMDA plus MK801 was evaluated on Cardiac electrophysiology parameters and incidence of ventricular arrhythmias (p=<0.01). Chronic NMDA administration in Wistar rats prolonged repolarization, induced electrical instability, and facilitated ventricular arrhythmias (P<0.01), which were normalized by MK801 co-treatment.
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