Subversion of Cell Signaling by Pathogens

Pathogens exploit several eukaryotic signaling pathways during an infection. They have evolved specific effectors and toxins to hijack host cell machinery for their own benefit. Signaling molecules are preferentially targeted by pathogens because they globally regulate many cellular processes. Both viruses and bacteria manipulate and control pathways that regulate host cell survival and shape, including MAPK signaling, G-protein signaling, signals controlling cytoskeletal dynamics, and innate immune responses. Outline 1 Introduction 2 Corruption of MAPK signaling 3 Manipulation of G-protein signaling 4 Highjacking lipid signaling 5 Other actin regulators targeted by pathogens 6 Targeting ubiquitin-mediated signal transduction 7 Conclusion