Key result
Obese children aged 4 to 12 years had significantly greater serum hs-CRP, urinary PGF-2α levels, and carotid intima media thickness compared to healthy controls.
Why the study?
Childhood obesity-related inflammation promotes atherosclerosis, but the relationships between inflammatory status, oxidative stress, and early arterial wall anomalies in obese children needed investigation.
Are serum hs-CRP and urinary PGF-2α associated with increased carotid intima media thickness in obese children?
Cross-Sectional (n=65)
No
Are serum hs-CRP and urinary PGF-2α associated with increased carotid intima media thickness in obese children?
Serum CRP and urinary PGF-2α are significantly elevated in obese children and correlate with increased carotid IMT, suggesting their utility as markers for early cardiovascular risk.
Answers are grounded in this paper and cite their sources.
hs-CRP and PGF-2α may signal early vascular changes in obese children; leaves open predictive value and need for longitudinal studies.
Background: Obese children of all ages show signs of low-grade chronic inflammation. Circulating acute phase reactants (CPR) and urinary PGF-2α are used to determine the severity of inflammation. Childhood obesity-related inflammation seems to have a key role in the advancement of atherosclerosis. Obesity is a key contributor in the evolution of metabolic disorder and collection of cardiovascular risk variables that may lead to heart illness and stroke. Doppler ultrasound estimations of the intima media thickness (IMT) are a practical, direct, and noninvasive method for evaluating and detecting preclinical artery wall diseases. It was connected to cardiovascular risk variables and was able to foresee the likelihood of future cardio-cerebrovascular disease. Objectives: The aim of this research was to look into inflammatory status as measured by serum highly sensitive acute phase reactants (hs-CPR), oxidative stress as measured by urinary PGF-2α, early arterial wall anomalies as measured by IMT, and associations between the above studied parameters, clinical, and anthropometric measurements. Methods: The research included 40 obese children aged 4 to 12 years who were chosen from The Outpatient Clinic of Children University Hospital, Faculty of Medicine, Minia University. A control group of 25 age and sex matched seemingly healthy youngsters was also recruited. Patients and controls had a comprehensive clinical assessment and had their serum hs-CRP and urine PGF-2α levels analyzed. High-resolution B-mode ultrasonography was used to assess IMT in the right and left carotid arteries. Results: Serum hs-CRP and PGF-2α levels in obese children were considerably greater than in controls. Obese juvenile patients had considerably greater median values of the left and right carotid arteries than controls. Conclusion: Serum CRP and Urinary PGF- 2α were the most important and statistically significant factors affecting IMT and can predict CVD risk in obese children.
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Bakry et al. (2022) conducted a cross-sectional in Obesity (n=65). Obesity vs. Healthy controls was evaluated on Serum hs-CRP, urinary PGF-2α, and carotid intima media thickness. Obese children aged 4 to 12 years had significantly greater serum hs-CRP, urinary PGF-2α levels, and carotid intima media thickness compared to healthy controls.
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