Key result
Compared to 20 controls, 32 obese children demonstrated significantly impaired flow-mediated vasodilation, increased intima-media thickness, and elevated E-selectin and thrombomodulin.
Why the study?
Do obese children have impaired vascular status and elevated endothelial plasma markers compared to controls?
Population
52 children (32 obese children and 20 control subjects)
Design
Case-control
Authors
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May indicate early vascular risk in obese children; hypothesis-generating and should not yet change practice.
Case-Control (n=52)
Do obese children have impaired vascular status and elevated endothelial plasma markers compared to controls?
Obese children exhibit early signs of atherosclerosis, including impaired endothelial function and increased intima-media thickness, highlighting the need for early cardiovascular risk screening.
Meyer et al. (2006) conducted a case-control in Childhood obesity (n=52). Obesity vs. Controls was evaluated on Vascular status (flow-mediated vasodilation, intima-media thickness) and plasma surrogate endothelial markers. Compared to 20 controls, 32 obese children demonstrated significantly impaired flow-mediated vasodilation, increased intima-media thickness, and elevated E-selectin and thrombomodulin.
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