Why the study?
Does obesity impair endothelial and smooth muscle function and cause arterial remodeling in pre-pubertal children compared to lean children?
Population
71 pre-pubertal children (48 obese and 23 lean), mean age 8.8 +/- 1.5 years.
Comparison
Obesity vs Lean body weight
Design
Cross-sectional
Authors
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Early vascular dysfunction may precede remodeling in obese children; hypothesis-generating and requires longitudinal validation before practice change.
Does obesity impair endothelial and smooth muscle function and cause arterial remodeling in pre-pubertal children compared to lean children?
Obesity in pre-pubertal children is associated with impaired endothelial and smooth muscle function and elevated ambulatory blood pressure, preceding structural arterial remodeling.
Aggoun et al. (2008) studied this question.
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