Key result
Obesity in children was associated with significantly higher abdominal arterial stiffness, including increased pressure strain elastic modulus (242.6 vs 164.2; P<0.001) compared to healthy controls.
Why the study?
Are abdominal arterial stiffness parameters increased in obese children compared to healthy controls, and do they correlate with cardiovascular risk factors?
Case-Control (n=72)
Are abdominal arterial stiffness parameters increased in obese children compared to healthy controls, and do they correlate with cardiovascular risk factors?
Absolute Event Rate: 242.6% vs 164.2%
p-value: p=<0.001
Abdominal arterial stiffness parameters are increased in obese children and correlate with insulin resistance, serving as useful markers for identifying cardiovascular risk.
May support early vascular assessment in obese children; leaves open prognostic value and need for prospective validation.
BACKGROUND: Limited data are available related to the effects of cardiovascular risk factors on abdominal arterial stiffness using carotid and brachial artery indices. Therefore, we aimed to determine arterial changes in obese children and investigate any relation with cardiovascular risk factors. METHODS: Thirty-eight obese children (mean body mass index: 28.35 ± 4.65 kg/m(2) ) and 34 age- and sex-matched healthy subjects underwent ultrasound measurements of abdominal, carotid and brachial arteries. Aortic strain, pressure strain elastic modulus (Ep), pressure strain normalized by diastolic blood pressure (Ep*), carotid intima-media thickness, carotid artery compliance, brachial artery flow-mediated dilatation, and well-known cardiovascular risk factors were assessed in the obese children. RESULTS: Obese children had significantly higher Ep and Ep* parameters than the healthy controls (mean: 242.6 [107.1-666.6], 164.2 [110.6-231.5]; P < 0.001, and mean: 3.39 [1.76-7.5], 2.64 [1.46-4.2]; P < 0.001, respectively). Ep and Ep* were significantly correlated with the homeostasis model assessment of insulin resistance (r = 0.587, P = 0.001; r = 0.467, P = 0.004, respectively). Receiver-operator curve analysis of Ep for identification of children with cardiovascular risk factors showed that the area under the curve for hyperinsulinemia was 0.80 (P < 0.001) and for hypertriglyceridemia was 0.62 (P < 0.01). CONCLUSIONS: Abdominal arterial stiffness parameters as well as carotid intima-media thickness and brachial arterial flow-mediated dilatation assessment were similarly useful in identifying obese children with cardiovascular risk factors. Insulin resistance is related with the augmented rigidity of the aortic wall in obese children.
No takes yet. Share an insight, caveat, or question.
Güven et al. (2013) conducted a case-control in Obesity (n=72). Obesity vs. Healthy controls was evaluated on Pressure strain elastic modulus (Ep) (p=<0.001). Obesity in children was associated with significantly higher abdominal arterial stiffness, including increased pressure strain elastic modulus (242.6 vs 164.2; P<0.001) compared to healthy controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: