Key result
Aortic strain was significantly higher in obese children (20.70%) compared to healthy normal-weight children (7.06%, p<0.001), indicating altered aortic elasticity parameters associated with increased body mass index.
Why the study?
Aortic elasticity is a predictor of future cardiovascular events in children, prompting evaluation of aortic stiffness in obese and overweight children compared to healthy ones.
Does obesity or overweight status alter aortic elasticity parameters in children?
Case-Control (n=98)
No
Does obesity or overweight status alter aortic elasticity parameters in children?
Obesity and overweight status in children are associated with altered aortic elasticity parameters, suggesting early vascular changes that may predispose to future cardiovascular disease.
Answers are grounded in this paper and cite their sources.
Aortic changes in obese children merit monitoring; leaves open whether they predict adult CVD or warrant intervention.
BACKGROUND: Aortic elasticity is a predictor and recognized factor for future cardiovascular events in children. The aim of the study was to evaluate the aortic stiffness in obese and overweight children compared to healthy ones. METHODS: The study evaluated 98 sex matched children aged 4 to 16 years that were equally distributed in asymptomatic obese or overweight and healthy children groups. All the participants were free of any heart diseases. Arterial stiffness indices were determined using two-dimensional echocardiography. RESULTS: The mean ages in the obese and healthy children were 10.40±2.50 years and 10.06±1.53 years, respectively. Aortic strain was significantly higher in obese children (20.70±5.04%), compared to healthy (7.06±3.77%) and overweight children (18.59±8.08%, p < 0.001). Aortic distensibility (AD) was significantly higher in obese children (0.010±0.005 cm < sup > 2 < /sup > dyn-1x10-6), compared to healthy (0.0036±0.004 cm < sup > 2 < /sup > dyn-1x10 < sup > -6 < /sup > ) and overweight children (0.009±0.005 cm < sup > 2 < /sup > dyn-1x10 < sup > -6 < /sup > , p < 0.001). Aortic strain beta (ASβ) index, was significantly higher in healthy children (9.26±6.17). Pressure-strain elastic modulus (PSEM) was significantly higher in healthy children (7.52±4.76 kPa). Systolic blood pressure increased with body mass index (BMI) significantly (p < 0.001) but diastolic blood pressure did not change (p=0.143). BMI had significant effect on arterial stiffness (AS) (β=0.732, p < 0.001), AD (β=0.636, p < 0.001), ASβ index (β=-0.573, p < 0.001) and PSEM (β=-0.578, p < 0.001). Age had significant effect on systolic diameter of the aorta (β=0.340, p < 0.001) and diastolic diameter of the aorta (β=0.407, p < 0.001). CONCLUSIONS: We concluded that aortic strain and aortic distensibility increased in obese children when aortic strain beta index and PSEM decreased. This result suggests that, as atrial stiffness is a predictor for future heart diseases, dietary treatment for children with overweight or obese status is important.
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Noori et al. (2023) conducted a case-control in Obesity and overweight (n=98). Obesity and overweight vs. Healthy normal-weight children was evaluated on Aortic strain (p=<0.001). Aortic strain was significantly higher in obese children (20.70%) compared to healthy normal-weight children (7.06%, p<0.001), indicating altered aortic elasticity parameters associated with increased body mass index.
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