Key result
Obese children had significantly higher posterior wall dimension in diastole (0.51 vs 0.46) and left ventricular mass index compared to healthy children, alongside reduced aortic elasticity.
Why the study?
The study was conducted to compare conventional echocardiography, aortic elasticity, and lipid profiles between overweight or obese children and healthy controls.
Does obesity or overweight status alter echocardiographic parameters and aortic elasticity in children compared to healthy controls?
Case-Control (n=98)
No
Does obesity or overweight status alter echocardiographic parameters and aortic elasticity in children compared to healthy controls?
Absolute Event Rate: 0.51% vs 0.46%
p-value: p=<0.001
Obese and overweight children exhibit significant adverse alterations in cardiac structure, function, and aortic elasticity compared to healthy peers, with further changes associated with abnormal lipid profiles.
May suggest early vascular changes in obese children; hypothesis-generating and requires prospective validation before clinical use.
Objectives: To compare conventional echocardiography, aortic elasticity and lipid profiles in overweight or obese children with healthy controls. Methodology: This case control study was conducted on 49 obese or overweight children aged 4 to 16 years, equally matched in age and sex of control that were normal regarding body mass index. Echocardiography and aortic elasticity findings measured for both groups and lipid profiles measured for overweight or obese children only. Data analyzed by SPSS 20 considering 0.05 as significant level. Results: Most of the echocardiography findings such as LVDS(P<0.001), LVDD(P<0.001), PWD(P<0.001), IVSS(P<0.001), LVMI(P<0.001), AS(P<0.001), AD(P<0.001) were higher significantly in obese children whereas, FS(P<0.001), FS(P<0.001), AS beta index(P<0.001) and PSEM(P<0.001) were lower compared to healthy. PWD was higher in obese (0.51±0.08 vs 0.46±0.07) compared to healthy children. Among obese or overweight children, aortic diameter in systole (AoS) (p=0.025) was higher in those with high triglyceride level. LVMI changed from those who had LDL >130. Those who had abnormal LDL (>130) had lower value of AOS (p=0.017). Systolic BP was correlated with AD (p=0.007), Diastolic BP with AS beta Index (p=0.006), AoD with AS (p=0.002), with AD (p<0.001), with AS beta Index (p=0.001) and with PSEM (P<0.001) Conclusion: Heart functions were most at risk in obese children. Amongst obese or overweight children, PWD was higher, when all other heart function were similar. LVMI was higher in children with elevated LDL level.
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Noori et al. (2021) conducted a case-control in Obesity and overweight in children (n=98). Obesity or overweight vs. Healthy children with normal BMI was evaluated on Posterior wall dimension in diastole (PWD) (p=<0.001). Obese children had significantly higher posterior wall dimension in diastole (0.51 vs 0.46) and left ventricular mass index compared to healthy children, alongside reduced aortic elasticity.
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