Abnormal myocardial deformation properties in obese, non-hypertensive children: an ambulatory blood pressure monitoring, standard echocardiographic, and strain rate imaging study
Why the study?
Does obesity without hypertension impair myocardial deformation properties in children?
Population
300 children, comprising 150 obese children without arterial hypertension and 150 healthy lean children…
Comparison
Obesity (observational exposure) vs Healthy lean children
Design
Cross-sectional
Authors
Discussion
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Implication
May indicate early biventricular impairment in obese normotensive children; hypothesis-generating and requires prospective studies before clinical use.
Structured PICO
Does obesity without hypertension impair myocardial deformation properties in children?
P
Population
300 children, comprising 150 obese children without arterial hypertension (mean age 12+/-3 years) and 150 healthy lean children comparable for age, sex, and pubertal stage (mean age 12+/-3 years).
I
Intervention
Obesity (observational exposure)
C
Comparator
Healthy lean children
O
Outcome
Preclinical effects of obesity on the cardiovascular system, specifically myocardial deformation properties measured by ultrasonic-derived strain and strain rate (SR) imagingsurrogate
Obesity in children, even in the absence of hypertension, is associated with significant subclinical impairment of longitudinal myocardial deformation properties in both ventricles.
Cite This Study
Salvo et al. (2006) studied this question.