Key result
Childhood obesity without hypertension is linked to greater LV mass and subclinical cardiac dysfunction.
Why the study?
Does obesity in children without hypertension cause subclinical systolic and diastolic cardiac dysfunction?
Cross-Sectional (n=50)
Does obesity in children without hypertension cause subclinical systolic and diastolic cardiac dysfunction?
Obesity in normotensive children is associated with subclinical systolic and diastolic cardiac dysfunction detectable by tissue Doppler imaging.
Answers are grounded in this paper and cite their sources.
May warrant closer cardiac monitoring in obese normotensive children; hypothesis-generating and should not yet change practice.
Background: The prevalence of obesity is increasing worldwide. Obese children without hypertension are becoming an important health challenge. Aims: Complications of obesity in adults are well established, but in obese children, cardiac dysfunction has not been reported clinically. Settings and Design: The present crosssectional study investigates subclinical systolic and diastolic dysfunction using echocardiographic modalities. Materials and Methods: Twentyfive youngsters with body mass index (BMI) >30 and 25 healthy children with BMI <25 were assigned into case and control group, respectively. In all participants, complete cardiovascular examination, electrocardiography, and echocardiography were fulfilled. Echocardiography surveys included standard, pulsed wave Doppler (PWD), and tissue Doppler imaging (TDI). Statistical Analysis Used: SPSS software, version 24. Results: The two groups were matched for age and sex. The resting heart rate and blood pressure were markedly higher in the obese group (P = 0.0001) though they were within the normal range in either category. Ejection fraction in the two groups was similar. Left ventricular (LV) mass (P = 0.0001), LV mass index (P = 0.029), left atrialtoaortic diameter ratio (P = 0.0001), and LV enddiastolic diameter (P = 0.008) were significantly greater in the case group, indicating cardiomegaly and subclinical systolic and diastolic dysfunction. Except for the aortic velocity, all PWD variables were considerably lower in the case group, suggesting subclinical diastolic dysfunction. All TDI parameters varied significantly between the two categories. There was a direct correlation between isovolumetric relaxation time and BMI. Conclusions: Obesity in children without hypertension is associated with subclinical systolic and diastolic cardiac dysfunction. We propose the evaluation of blood pressure as well as myocardial performance using PWD and TDI in all obese children without hypertension, regularly.
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Sharifi et al. (2018) conducted a cross-sectional in Obesity without hypertension (n=50). Obesity (BMI >30) vs. Healthy children (BMI <25) was evaluated on Subclinical systolic and diastolic dysfunction using echocardiographic modalities. Obesity in children without hypertension was associated with significantly greater LV mass (P=0.0001) and altered Doppler parameters, indicating subclinical cardiac dysfunction.
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