Key result
Adolescent obesity is linked to ~49% higher LVMI and subclinical diastolic dysfunction versus normal-weight controls.
Why the study?
Obesity is associated with increased blood volume, left ventricular hypertrophy, and diastolic dysfunction in childhood, prompting examination of the relationship between BMI, waist/hip ratio, structural cardiac changes, and systolic and diastolic functions in obese adolescents.
Does obesity alter ventricular geometry and cardiac functions in adolescents aged 12-18 years?
Cross-Sectional (n=140)
No
Does obesity alter ventricular geometry and cardiac functions in adolescents aged 12-18 years?
Absolute Event Rate: 50.86% vs 34.03%
p-value: p=<0.001
Obesity in adolescents is associated with early subclinical structural and functional cardiac changes, including increased left ventricular mass and diastolic dysfunction.
Hypothesis-generating for cardiac screening in obese adolescents; prospective studies needed to assess reversibility and outcomes.
Objective: Obesity is a serious condition associated with increased blood volume and left ventricular hypertrophy, with diastolic dysfunction being particularly prominent during childhood. In adulthood, systolic dysfunction is more commonly observed. The aim of this study is to examine the relationship between body mass index (BMI), waist/hip ratio, and the structural changes in the heart, as well as systolic and diastolic functions, in obese adolescents. Methods: The study included 80 obese and 60 normal-weight adolescents aged between 12-18 years. The body mass index (BMI) of all participants was calculated, and their systolic and diastolic blood pressures were measured. Lipid profile and insulin resistance assessments were conducted for the obese adolescents, and waist/hip ratio was calculated. M-mode echocardiography, pulsed Doppler, and tissue Doppler echocardiography were performed on all subjects to evaluate cardiac functions. Results: The results showed that systolic and diastolic blood pressure were higher in obese adolescents compared to the control group. Left ventricular mass index (LVMI), epicardial adipose tissue (EAT), and carotid intima-media thickness (CIMT) were also found to be higher in the obese group. Additionally, a significant decrease was detected in markers of diastolic dysfunction. No systolic dysfunction was observed; however, the left ventricular Tei index (LVTEI), which reflects both systolic and diastolic dysfunction, was significantly higher in the obese group. Conclusion: This study demonstrates that cardiac dysfunction can be detected in obese adolescents before symptoms appear, providing an opportunity for early intervention
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Türk et al. (2025) conducted a cross-sectional in Obesity (n=140). Obesity vs. Normal-weight healthy adolescents was evaluated on Left ventricular mass index (LVMI) in g/m2 (p=<0.001). Obese adolescents exhibited significantly higher left ventricular mass index (median 50.86 vs 34.03 g/m2) and markers of subclinical diastolic dysfunction compared to normal-weight controls.
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