What question did this study set out to answer?

To evaluate the impact of obesity on endothelial function and arterial stiffness in children and adolescents and examine their associations with cardiovascular risk factors.

January 1, 2013Hormone Research in PaediatricsOpen Access

Arterial Stiffness and Endothelial Function in Obese Children and Adolescents and Its Relationship with Cardiovascular Risk Factors

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Why the study?

Does obesity impair vascular function (endothelial function and arterial stiffness) in children and adolescents?

Population

57 children and adolescents, comprising 37 obese and 20 non-obese individuals.

Comparison

Obesity (exposure) vs Non-obese

Design

Cross-sectional

Authors

CTClaudio Joo TuroniNational University of Tucumán RMRodrigo O. MarañónGeneral / Preventive / Lipids VFVerónica FelipeNational University of Villa María

Discussion

Member takes

Implication

Obesity may impair vascular function in youth; hypothesis-generating for early interventions but requires longitudinal confirmation before practice change.

Key Points

To evaluate the impact of obesity on endothelial function and arterial stiffness in children and adolescents and examine their associations with cardiovascular risk factors.
Assessed endothelial function via reactive hyperemia and arterial stiffness via index of digital volume waveforms using pulse plethysmography in obese youth (n=37) versus non-obese controls (n=20; BMI >10th to <97th percentile).
Measured anthropometric metrics, body fat percentage, lipid profile, fasting glucose, insulinemia, HOMA-IR, and hemodynamic parameters in both groups.
Endothelial function was significantly lower in the obese group (15.8 ± 0.2%, n=37) compared to the non-obese group (41.4 ± 5%, n=20; p < 0.001), alongside increased arterial stiffness.
BMI, body weight, waist circumference, body fat percentage, insulinemia, and HOMA-IR were significantly elevated in the obese cohort.
Endothelial function was negatively correlated with waist circumference and HOMA-IR in obese participants, whereas insulinemia correlated positively with HOMA-IR.

Structured PICO

Does obesity impair vascular function (endothelial function and arterial stiffness) in children and adolescents?

Population

57 children and adolescents, comprising 37 obese and 20 non-obese individuals.

Intervention

Obesity (exposure)

Comparator

Non-obese (body mass index >10th to <97th percentile)

Outcome

Vascular function (endothelial function and arterial stiffness evaluated by pulse plethysmography)surrogate

Obesity in children and adolescents is associated with early impairment of vascular function, highlighting the need for early lifestyle interventions to prevent cardiovascular disease.

Cite This Study

Turoni et al. (2013) studied this question.

synapsesocial.com/papers/6a710c78ac440176ef29b8f4 https://doi.org/10.1159/000354991

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Implication

Obesity may impair vascular function in youth; hypothesis-generating for early interventions but requires longitudinal confirmation before practice change.

Arterial Stiffness and Endothelial Function in Obese Children and Adolescents and Its Relationship with Cardiovascular Risk Factors

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Arterial Stiffness and Endothelial Function in Obese Children and Adolescents and Its Relationship with Cardiovascular Risk Factors

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider