Key result
Overweight children had significantly increased right and left mean cIMT (0.58 vs 0.44 mm and 0.56 vs 0.44 mm, P<.001) and decreased FMD (6.25% vs 7.69%, P<.001) compared to normal weight controls.
Why the study?
Does overweight status increase early atherosclerosis markers (cIMT and FMD) in children?
Cross-Sectional (n=182)
Does overweight status increase early atherosclerosis markers (cIMT and FMD) in children?
Overweight children exhibit early signs of atherosclerosis, including increased carotid intima-media thickness and decreased flow-mediated dilatation, highlighting the cardiovascular risks of childhood overweight status.
May warrant vigilance for vascular risk in overweight youth; hypothesis-generating for longitudinal causality and intervention trials.
We measured brachial artery flow-mediated dilatation (FMD) and common carotid intima-media thickness (cIMT) in overweight (n = 67) and normal weight children (n = 115, controls). Age at examination ranged from 72 to 182 months (mean 123 ± 27). Compared to controls, the overweight children had increased weight, waist and hip circumference, systolic and diastolic blood pressures (all P < .001), right and left mean cIMT (mm; 0.58 [0.42-0.68] vs 0.44 [0.3-0.64], P < .001 and 0.56 [0.32-0.70] vs 0.44 [0.3-0.60], P < .001), respectively, and decreased FMD (%; 6.25 [3.33-19.05] vs 7.69 [3.45-16], P < .001). The cIMT and FMD were closely related to the serum insulin concentrations. Age, waist circumferences, and serum triglycerides were independent predictive risk factors for increased cIMT, and fasting glucose and BMI were independent predictive variables for decreased FMD. Overweight children are also potentially at risk of early atherosclerosis as much as obese children.
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Alpsoy et al. (2013) conducted a cross-sectional in Overweight (n=182). Overweight vs. Normal weight was evaluated on Right mean common carotid intima-media thickness (cIMT) in mm (p=<.001). Overweight children had significantly increased right and left mean cIMT (0.58 vs 0.44 mm and 0.56 vs 0.44 mm, P<.001) and decreased FMD (6.25% vs 7.69%, P<.001) compared to normal weight controls.
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