Key result
Inhibition of the RhoA/ROCK pathway can prevent endothelial dysfunction in a variety of pathological conditions by restoring the balance of vasodilating and vasoconstricting substances.
This review highlights the mechanistic role of the RhoA/ROCK pathway in endothelial dysfunction and its potential as a therapeutic target for vascular disease.
Endothelial dysfunction is a key event in the development of vascular disease, and it precedes clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase (ROCK) pathway has been found to elevate vascular tone through unbalancing the production of vasodilating and vasoconstricting substances. Inhibition of the RhoA/ROCK pathway can prevent endothelial dysfunction in a variety of pathological conditions. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of the ROCK pathway and its roles in endothelial dysfunction.
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Yang et al. (2010) conducted a review in Endothelial dysfunction. RhoA/ROCK pathway inhibition was evaluated. Inhibition of the RhoA/ROCK pathway can prevent endothelial dysfunction in a variety of pathological conditions by restoring the balance of vasodilating and vasoconstricting substances.
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