Key result
The AGTR1 rs1492099 minor allele-containing genotype polymorphisms were significantly associated with an increased risk of AVF malfunction in male hemodialysis patients (adjusted OR 3.63, p=0.005).
Why the study?
Do genetic polymorphisms of RAAS-related genes increase the risk of arterio-venous fistula malfunction in hemodialysis patients?
Cross-Sectional (n=577)
Yes
Do genetic polymorphisms of RAAS-related genes increase the risk of arterio-venous fistula malfunction in hemodialysis patients?
Odds Ratio: 3.63
p-value: p=0.005
The AGTR1 gene single nucleotide polymorphism rs1492099 is a potential genetic risk factor for arterio-venous fistula malfunction in male hemodialysis patients.
May inform genetic risk assessment for AVF malfunction in male hemodialysis patients; hypothesis-generating and requires prospective validation.
Hemodialysis (HD) is the most commonly-used renal replacement therapy for patients with end-stage renal disease worldwide. Arterio-venous fistula (AVF) is the vascular access of choice for HD patients with lowest risk of infection and thrombosis. In addition to environmental factors, genetic factors may also contribute to malfunction of AVF. Previous studies have demonstrated the effect of genotype polymorphisms of angiotensin converting enzyme on vascular access malfunction. We conducted a multicenter, cross-sectional study to evaluate the association between genetic polymorphisms of renin-angiotensin-aldosterone system and AVF malfunction. Totally, 577 patients were enrolled. Their mean age was 60 years old and 53% were male. HD patients with AVF malfunction had longer duration of HD (92.5 ± 68.1 vs. 61.2 ± 51.9 months, p < 0.001), lower prevalence of hypertension (44.8% vs. 55.3%, p = 0.025), right-sided (31.8% vs. 18.4%, p = 0.002) and upper arm AVF (26.6% vs. 9.7%, p < 0.001), and higher mean dynamic venous pressure (DVP) (147.8 ± 28.3 vs. 139.8 ± 30.0, p = 0.021). In subgroup analysis of different genders, location of AVF and DVP remained significant clinical risk factors of AVF malfunction in univariate and multivariate binary logistic regression in female HD patients. Among male HD patients, univariate binary logistic regression analysis revealed that right-side AVF and upper arm location are two important clinical risk factors. In addition, two single nucleotide polymorphisms (SNPs), rs275653 (Odds ratio 1.90, p = 0.038) and rs1492099 (Odds ratio 2.29, p = 0.017) of angiotensin II receptor 1 (AGTR1), were associated with increased risk of AVF malfunction. After adjustment for age and other clinical factors, minor allele-containing genotype polymorphisms (AA and CA) of rs1492099 still remained to be a significant risk factor of AVF malfunction (Odds ratio 3.63, p = 0.005). In conclusion, we demonstrated that rs1492099, a SNP of AGTR1 gene, could be a potential genetic risk factor of AVF malfunction in male HD patients.
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Chen et al. (2016) conducted a cross-sectional in End-stage renal disease requiring hemodialysis with arterio-venous fistula (n=577). Genetic polymorphisms of renin-angiotensin-aldosterone system (AGTR1 rs1492099) vs. Absence of the minor allele-containing genotype polymorphisms was evaluated on Arterio-venous fistula (AVF) malfunction (OR 3.63, p=0.005). The AGTR1 rs1492099 minor allele-containing genotype polymorphisms were significantly associated with an increased risk of AVF malfunction in male hemodialysis patients (adjusted OR 3.63, p=0.005).
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