Key result
The CYP4A11 rs9333025 GG genotype significantly increased susceptibility to ischemic stroke (OR 1.82) and was independently associated with a higher risk of atherothrombotic events after stroke (RR 1.87).
Why the study?
Does the CYP4A11 rs9333025 GG genotype increase susceptibility to ischemic stroke and subsequent atherothrombotic events in Chinese patients?
Case-Control (n=774)
Yes
Does the CYP4A11 rs9333025 GG genotype increase susceptibility to ischemic stroke and subsequent atherothrombotic events in Chinese patients?
Odds Ratio: 1.82 (95% CI 1.24–5.04)
Absolute Event Rate: 75.5% vs 65.6%
p-value: p=0.016
The CYP4A11 rs9333025 GG genotype increases susceptibility to ischemic stroke and is an independent predictor of recurrent atherothrombotic events at 12 months in Chinese patients.
May support risk stratification in Chinese stroke patients; leaves open prospective validation before clinical adoption.
To evaluate the associations between four single-nucleotide polymorphisms (SNPs) in CYP4A11 and CYP4F2 and ischemic stroke (IS), and between these variants and atherothrombotic events after stroke. IS patients (n=396) and controls (n=378) were genotyped for two CYP4A11 SNPs (rs2269231 and rs9333025) and two CYP4F2 SNPs (rs2108622 and rs3093135). Patients were followed up for 12 months after the stroke for the atherothrombotic events. The frequency of the rs9333025 GG genotype was significantly higher in IS patients than in controls. Logistic regression analysis showed that the presence of rs9333025 GG in patients was associated with significantly higher risk of IS. Cox regression analysis revealed that the rs9333025 GG genotype was an independent risk factor for atherothrombotic events after stroke. The rs9333025 GG genotype increases patients' susceptibility to IS and is associated with high frequencies of atherothrombotic events in stroke patients.
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Zhang et al. (2015) conducted a case-control in Ischemic stroke (n=774). CYP4A11 rs9333025 GG genotype vs. Non-GG genotypes or healthy controls was evaluated on Susceptibility to ischemic stroke (OR 1.82, 95% CI 1.24-5.04, p=0.016). The CYP4A11 rs9333025 GG genotype significantly increased susceptibility to ischemic stroke (OR 1.82) and was independently associated with a higher risk of atherothrombotic events after stroke (RR 1.87).
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