Key result
Passive leg movement leg blood flow responses were weakly positively associated with brachial artery reactive hyperemia (r=0.33 to 0.37, p<0.01) but not with FMD% (p>0.30) in healthy young women.
Why the study?
Are lower-limb resistance artery function assessments via passive leg movement (PLM) associated with upper-limb conduit artery (FMD%) and resistance artery (reactive hyperemia) function assessments in healthy young premenopausal women?
Cross-Sectional (n=72)
No
Are lower-limb resistance artery function assessments via passive leg movement (PLM) associated with upper-limb conduit artery (FMD%) and resistance artery (reactive hyperemia) function assessments in healthy young premenopausal women?
In healthy young women, lower-limb resistance artery function assessed by passive leg movement correlates weakly with upper-limb resistance artery reactive hyperemia but not with brachial artery FMD%, indicating these tests capture distinct aspects of vascular function and cannot be used interchangeably.
Answers are grounded in this paper and cite their sources.
PLM and reactive hyperemia capture distinct vascular aspects; leaves open their interchangeability as microvascular measures in young women.
Upper- and lower-limb indices of resistance artery function are positively associated in young women when assessed by reactive hyperemia following brachial artery flow-mediated dilation (FMD) cuff-occlusion release and leg blood flow responses to passive leg movement (PLM), respectively. However, despite previous data demonstrating a positive association between upper-limb conduit artery function assessed by FMD and lower-limb resistance artery function assessed by PLM in young men, these measures do not appear to be related in young women.
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D’Agata et al. (2022) conducted a cross-sectional in Healthy premenopausal women (n=72). Passive leg movement (PLM) leg blood flow responses vs. Brachial artery flow-mediated dilation (FMD%) and reactive hyperemia (RH) was evaluated on Association between lower-limb resistance artery function (PLM leg blood flow responses) and upper-limb resistance artery (brachial artery RH) and conduit artery (FMD%) function (r=0.33 for ΔBABF and ΔLBF; r=0.33 for BABF AUC and LBF AUC; r=0.37 for BABFpeak and LBFpeak, p=<0.01). Passive leg movement leg blood flow responses were weakly positively associated with brachial artery reactive hyperemia (r=0.33 to 0.37, p<0.01) but not with FMD% (p>0.30) in healthy young women.
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