Key result
Combining neutrophil-lymphocytic ratio and 2D echo calcium score predicted obstructive CAD in type II diabetic patients with 90.9% sensitivity and 72.2% specificity.
Why the study?
Early detection of CAD in type II DM is important, and NLR and echo calcium score were recently identified as independent CAD predictors.
Do 2D echo calcium score and neutrophil/lymphocyte ratio predict obstructive coronary artery disease in male patients with type II diabetes?
Cross-Sectional (n=40)
Do 2D echo calcium score and neutrophil/lymphocyte ratio predict obstructive coronary artery disease in male patients with type II diabetes?
Combining 2D echo calcium score and neutrophil-lymphocytic ratio provides a simple, sensitive tool for predicting obstructive CAD in diabetic men.
NLR and eCS may aid obstructive CAD prediction in type II diabetes; leaves open validation in larger cohorts before clinical adoption.
Background Early detection of coronary artery disease (CAD) among patients with type II diabetes mellitus (DM) constitutes an important task. Neutrophil-lymphocytic ratio (NLR) and echo calcium score (eCS) have been recently identified as independent predictors of CAD. Aim The study aimed to assess the value of 2D echo calcium score and NLR as simple tools for the prediction of CAD documented by multislice computed tomography in type II diabetic patients. Patients and methods The study included 40 male patients with type II DM and known risk factors for CAD, who were referred for coronary computed tomography (CT) due to suspected CAD. NLR and eCS were assessed in all patients. Coronary calcium score and the presence of obstructive CAD were assessed by CT coronary angiography. Results Patients were divided into two groups according to the presence of CAD; group I (18 patients) with nonobstructive CAD and group II (22 patients) with obstructive CAD. The authors found that patients in group II had significantly higher NLR, eCS, and coronary artery calcium score (CACS) compared with group I. There was a weak positive correlation between NLR and coronary calcium score and a strong positive correlation between eCS and CACS. The best sensitivity and specificity of eCS and NLR were 77.3, 66.7 and 77.3, 61.1%, respectively, when used alone to predict obstructive CAD. However, when combining NLR and eCS, the capability to predict obstructive CAD increased with sensitivity (90.9%) and specificity (72.2%). Conclusion NLR and eCS had the capability to predict obstructive CAD detected by CT coronary angiography in patients with type II DM.
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Nasreldeen et al. (2020) conducted a cross-sectional in Type II diabetes mellitus with suspected coronary artery disease (n=40). 2D echo calcium score and neutrophil-lymphocytic ratio was evaluated on Obstructive CAD detected by CT coronary angiography. Combining neutrophil-lymphocytic ratio and 2D echo calcium score predicted obstructive CAD in type II diabetic patients with 90.9% sensitivity and 72.2% specificity.
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