Key result
Temporary pacing using an externalized active fixation lead successfully bridged a patient with immune checkpoint inhibitor-associated advanced atrioventricular block until conduction recovered.
Case Report (n=1)
Prolonged temporary pacing with an active fixation lead and externalized generator is a feasible bridging strategy for ICI-associated advanced AV block, which can be reversible, thereby avoiding unnecessary permanent pacemaker implantation.
May support prolonged temporary pacing in ICI-myocarditis with reversible AVB; leaves open need for prospective validation before broader adoption.
A case of immune checkpoint inhibitors (ICIs)-associated myocarditis with reversible advanced atrioventricular block (AVB) was reported. We innovatively used active fixation lead connected to an external device for prolonged temporary pacing until atrioventricular conduction recovered. Invasive electrophysiology studies were performed to evaluate atrioventricular conduction in detail. Long-term follow-up for nearly 120-days and repeated long-term electrocardiography was conducted to ensure the conduction system was truly recovered.
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Wang et al. (2024) conducted a case report in Immune checkpoint inhibitor-associated myocarditis with advanced atrioventricular block (n=1). Temporary pacing using active fixation lead was evaluated on Recovery of atrioventricular conduction. Temporary pacing using an externalized active fixation lead successfully bridged a patient with immune checkpoint inhibitor-associated advanced atrioventricular block until conduction recovered.
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