Key result
Overweight and obesity are paradoxically associated with better survival and lower event rates in cardiovascular patients, highlighting an inverse cardiovascular epidemiology.
Why the study?
Recent trials and meta-analyses showing negative correlations between body mass index and clinical outcomes have prompted debate on whether to correct overweight and obesity in cardiovascular patients as secondary prevention.
This review discusses the potential causes of the obesity paradox in cardiovascular disease, where higher BMI is sometimes associated with better clinical outcomes.
May support obesity paradox in CVD; leaves open causality and need for prospective trials.
Taken the continuous increase of obesity prevalence, most countries in the world deal with an epidemy, one of the main healthcare concerns. In the structure of nosology associated with overweight and obesity, cardiovascular is leading. Also, in the recent trials and meta analyses there is negative correlation found for body mass index and clinical outcomes characterizing better survival and lower events rate in those with higher BMI, as less chronic diseases. Such facts facilitated a number of discussions on the predictive value of overweight and obesity and consideration whether to correct those in cardiovascular patients as secondary prevention. Current article is focused on the main causes for an “inverse” cardiovascular epidemiology in overweight and obesity.
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Druzhilov et al. (2018) conducted a review in Cardiovascular disease and obesity. Overweight and obesity was evaluated. Overweight and obesity are paradoxically associated with better survival and lower event rates in cardiovascular patients, highlighting an inverse cardiovascular epidemiology.
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