Why the study?
The study was designed to assess the frequency and types of orthostatic hypotension and orthostatic hypertension and their associations with clinical characteristics, comorbidities, heart failure severity, and outcomes.
What is the frequency and role of orthostatic hypotension and hypertension in patients with chronic heart failure?
What is the frequency and role of orthostatic hypotension and hypertension in patients with chronic heart failure?
The ORTHO-HYPO study is designed to evaluate the frequency, types, and clinical impact of orthostatic blood pressure changes in patients with chronic heart failure.
As part of the observational, multicenter prospective study CardioReno-Hepato-Metabolic Disease in Chronic Heart Failure (CARMENCHF), an additional exploratory study of the types and role of hypotension in heart failure (ORTHO-HYPO) was specifically designed to thoroughly examine hypotension. The study aim is to assess the frequency and types of orthostatic hypotension and orthostatic hypertension and their associations with clinical and demographic characteristics, comorbidity, severity of clinical manifestations of heart failure, and outcomes. In this sub-study, in addition to the routine examination, an active "supine-standing" orthostatic test and 24-h blood pressure and ECG monitoring will be performed.
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Solovyova et al. (2026) studied this question.
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