Key result
ACE phenotyping combining activity determination and immunoreactive protein quantification unequivocally detected ACE inhibitors and established normal ACE values at 50%-150% of control pooled serum.
Why the study?
Elevated tissue and blood ACE levels are linked to increased cardiovascular and granulomatous disease risk, but precision characterization and normal reference values required a novel phenotyping approach.
Observational (n=300)
A novel ACE phenotyping approach combining activity determination and immunoreactive protein quantification enables the establishment of normal ACE values and detection of ACE inhibitor presence in blood.
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May inform cardiovascular risk assessment via ACE phenotyping; leaves open validation before clinical use.
Samokhodskaya et al. (2021) conducted an observational in Unrelated patients (n=300). ACE phenotyping was evaluated on Normal values of ACE in healthy populations. ACE phenotyping combining activity determination and immunoreactive protein quantification unequivocally detected ACE inhibitors and established normal ACE values at 50%-150% of control pooled serum.
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