Key result
Patients with STEMI and preserved LVEF had significantly higher serum concentrations of cardiac fibrosis markers PIIINP (3.6-fold) and PICP (3.4-fold) on the first day of hospitalization compared to healthy controls.
Why the study?
There is currently no method that accurately predicts an adverse outcome of HFpEF following STEMI.
Do serum markers of cardiac fibrosis (PICP and PIIINP) differ in patients with post-STEMI HFpEF compared to healthy controls?
Case-Control (n=103)
No
Do serum markers of cardiac fibrosis (PICP and PIIINP) differ in patients with post-STEMI HFpEF compared to healthy controls?
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Elevated serum procollagens (PICP and PIIINP) within 24 hours of STEMI indicate early cardiac fibrosis and may help predict the development of HFpEF.
Aim . Currently, there is no method which accurately predicts an adverse outcome of heart failure with a preserved left ventricular ejection fraction (HFpEF) upon ST-segment elevation myocardial infarction (STEMI). Here we studied the prognostic significance of procollagen type I C-terminal propeptide (PICP) and procollagen type III N-terminal propeptide (PIIINP) in patients with post-STEMI HFpEF. Material and Methods . The study included 83 patients (60 men and 23 women) with post-STEMI HFpEF (left ventricular EF ≥ 50%) and 20 ageand gender-matched healthy controls. Serum concentrations of PICP and PIIINP were measured on the 1st day of hospitalization using enzyme-linked immunosorbent assay with the following calculation of PICP/PIIINP ratio. Results . Serum PICP and PIIINP on the 1st day of STEMI significantly (3.4-fold) exceeded the values of the control group and were as follows: PIIINP: 26.0 (18.9; 34.9) ng/mL (р = 0.047); PICP: 609.0 (583.0; 635.0) ng/mL (р = 0.049). Conclusion . Elevated values of procollagens indicate that cardiac fibrosis commences within the 24 hours after STEMI onset. The pivotal role of cardiac fibrosis in the formation of diastolic dysfunction suggests the usefulness of serum procollagens to predict the development of HFpEF in a long-term period upon STEMI.
Осокина et al. (2021) conducted a case-control in ST-segment elevation myocardial infarction with preserved left ventricular ejection fraction (n=103). STEMI with preserved LVEF vs. Healthy controls was evaluated on Serum concentration of procollagen type I C-terminal propeptide (PICP) in ng/mL (p=0.047). Patients with STEMI and preserved LVEF had significantly higher serum concentrations of cardiac fibrosis markers PIIINP (3.6-fold) and PICP (3.4-fold) on the first day of hospitalization compared to healthy controls.
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