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November 1, 1985CirculationOpen Access

Comparison of pathologic and angiographic findings in a porcine preparation of coronary atherosclerosis.

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Why the study?

Does antemortem coronary angiography accurately reflect pathologic findings in a porcine model of coronary atherosclerosis?

Population

Yorkshire swine with induced coronary atherosclerosis

Comparison

Antemortem coronary angiography with Vernier… vs Pathologic examination with morphometric…

Design

Preclinical

Follow-up

8 months (atherogenic regimen duration)

Authors

BWBonnie H. WeinerBoston UniversityIOIra S. OckeneWorcester Polytechnic InstituteJJJ. JarmolychAlbany Medical Center Hospital

Discussion

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Implication

Supports QCA for focal stenoses in porcine models; leaves open accuracy for diffuse disease before clinical translation.

Structured PICO

Does antemortem coronary angiography accurately reflect pathologic findings in a porcine model of coronary atherosclerosis?

P
Population
Yorkshire swine with induced coronary atherosclerosis (via diet-induced hyperlipidemia and balloon intimal abrasion of a coronary artery)
I
Intervention
Antemortem coronary angiography with Vernier caliper measurements
C
Comparator
Pathologic examination with morphometric evaluation of perfusion-fixed coronary arteries
O
Outcome
Relationship between angiogram and pathology in the assessment of the extent and location of coronary atherosclerosissurrogate

Quantitative coronary angiography accurately localizes and quantifies focal stenoses in vivo, confirming its diagnostic value, though it may miss diffuse disease.

Limitations

  • Fixation and paraffin-processing artifact may have affected pathologic measurements of normal or minimally diseased vessels

Cite This Study

Weiner et al. (1985) studied this question.

synapsesocial.com/papers/6a74fb806a5eb4b8f5093f07https://doi.org/10.1161/01.cir.72.5.1081
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Also Consider

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  1. 1New micromethod for measuring cholesterol in plasma lipoprotein fractions.1977 · 211 citations
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