What question did this study set out to answer?

Characterize the structural and ultrastructural features of atypical intracellular inclusions found in muscle biopsies from a child with hypotonia and muscle weakness.

December 7, 1963JAMAOpen Access

Light and Electron Microscopic Studies of "Myogranules" in Child With Hypotonia and Muscle Weakness

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Authors

PCP.E. ConenLudwig-Maximilians-Universität München EME. Gordon MurphyUniversity of Liverpool WDW. L. DonohueThe University of Melbourne

Discussion

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Implication

Case report demonstrates novel rod-shaped myogranules in a child with hypotonia, suggesting an underlying disturbance of muscle proteins.

Key Points

Characterize the structural and ultrastructural features of atypical intracellular inclusions found in muscle biopsies from a child with hypotonia and muscle weakness.
Screened muscle biopsies from more than 100 individuals using light and electron microscopy.
Analyzed paraffin- and plastic-embedded thin sections from two gastrocnemius muscle biopsies taken from a 4-year-old boy presenting with non-progressive hypotonia and weakness.
Identified rod-shaped particles designated as myogranules, measuring 0.1 to 5 microns in length and oriented along the fiber long axis, which caused loss of normal cross-striations in affected areas.
Observed myofilaments traversing the myogranules with structural periodicity resembling recrystallized muscle protein paramyosin on electron micrographs.

Cite This Study

Conen et al. (1963) studied this question.

synapsesocial.com/papers/6a74fbb7f2cd31a1fadbf191 https://doi.org/10.1001/jama.1963.03710100122083

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December 7, 1963JAMAOpen Access

Light and Electron Microscopic Studies of "Myogranules" in Child With Hypotonia and Muscle Weakness

View Full Paper

Ask AI

Bookmark

Authors

PCP.E. ConenLudwig-Maximilians-Universität München EME. Gordon MurphyUniversity of Liverpool WDW. L. DonohueThe University of Melbourne

Discussion

Member takes

Implication

Case report demonstrates novel rod-shaped myogranules in a child with hypotonia, suggesting an underlying disturbance of muscle proteins.

Key Points

Characterize the structural and ultrastructural features of atypical intracellular inclusions found in muscle biopsies from a child with hypotonia and muscle weakness.
Screened muscle biopsies from more than 100 individuals using light and electron microscopy.
Analyzed paraffin- and plastic-embedded thin sections from two gastrocnemius muscle biopsies taken from a 4-year-old boy presenting with non-progressive hypotonia and weakness.
Identified rod-shaped particles designated as myogranules, measuring 0.1 to 5 microns in length and oriented along the fiber long axis, which caused loss of normal cross-striations in affected areas.
Observed myofilaments traversing the myogranules with structural periodicity resembling recrystallized muscle protein paramyosin on electron micrographs.

Cite This Study

Conen et al. (1963) studied this question.

synapsesocial.com/papers/6a74fbb7f2cd31a1fadbf191 https://doi.org/10.1001/jama.1963.03710100122083

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