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February 1, 1990Psychological Medicine

Perceptual and physiological dysfunction in depression

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Why the study?

Do depressed patients show altered P300 responses to emotive words compared to normal controls?

Population

Depressed patients (unipolar major), patients recovered from the same type of depression, and normal controls

Comparison

Assessment of P300 responses to emotive words of… vs Normal controls

Design

Case-control

Authors

IBI. M. BlackburnHRHilary M. RoxboroughWMWalter Muir

Discussion

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Overview

Altered P300 amplitude to emotive words may reflect emotional processing bias in depression; leaves open its value as a diagnostic biomarker.

Structured PICO

Do depressed patients show altered P300 responses to emotive words compared to normal controls?

P
Population
Depressed patients (unipolar major), patients recovered from the same type of depression, and normal controls
I
Intervention
Assessment of P300 responses to emotive words of different hedonic tones (negative, positive, neutral)
C
Comparator
Normal controls
O
Outcome
Amplitude and latency of P300 responses to emotive wordssurrogate

Depressed patients exhibit altered physiological processing (P300 amplitude) of emotive words, a pattern that persists even after recovery.

Cite This Study

Blackburn et al. (1990) studied this question.

synapsesocial.com/papers/6a74fbef84fffe492cdbdab2https://doi.org/10.1017/s003329170001326x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cognitive mechanism for meaning of emotive words in depressed personality : an evnet-related potential study2006
  2. 2The Specificity of Individuals with Depressive Tendencies in Processing Verbal Emotional Information: Evidence from ERP2026
  3. 3Emotional Stimulus Processing in Depression: Insights from the Investigation of Symptom-Specific Alterations of the Late Positive Potential2024
  4. 4Negative bias in early and late cognitive processing of coronary heart disease patients with depressive symptoms: an EPR study2023 · 4 citations
  5. 5Pupillary Response to Auditory Stimuli in Depressive State2016 · 4 citations