Key result
Statins do not improve overall prognosis in patients with chronic heart failure of any etiology, though they are safe and may reduce hospitalizations in ischemic cases.
Why the study?
Does statin therapy improve outcomes in patients with chronic heart failure?
Does statin therapy improve outcomes in patients with chronic heart failure?
Routine initiation of statins specifically for the treatment of chronic heart failure does not improve overall prognosis, though it remains safe to continue in patients with ischemic heart disease.
Does not support statin initiation for HF prognosis; leaves open ischemic hospitalization benefit for prospective trials.
Despite our knowledge about pathogenesis, clinical characteristics and treatment, chronic heart failure (CHF) remains widespread disease with poor prognosis. However, there is not a common opinion whether statins are reasonable in patients with CHF. The data about efficiency and safety of statins are contradictory and demand evidences due to regular exclusion of patients with CHF from the majority of clinical trials of statins. The reduction of the level of low-density lipoproteins is not the unique mechanism of favourable effect of statins in patients with CHF, therefore, their pleiotropic effects are considered very important.
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Драпкина et al. (2012) conducted a review in Chronic heart failure. Statins was evaluated. Statins do not improve overall prognosis in patients with chronic heart failure of any etiology, though they are safe and may reduce hospitalizations in ischemic cases.
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