Key result
Dietary nitrate supplementation for 3 days did not significantly alter peak cutaneous reactive hyperaemia compared to baseline in healthy humans (57 vs 52 % CVC max).
Why the study?
Does dietary nitrate supplementation augment cutaneous reactive hyperaemia in healthy humans?
Does dietary nitrate supplementation augment cutaneous reactive hyperaemia in healthy humans?
Absolute Event Rate: 57% vs 52%
Short-term dietary nitrate supplementation reduces diastolic blood pressure but does not alter cutaneous reactive hyperaemia in healthy humans.
No immediate clinical implications in healthy adults; leaves open effects in disease states or with longer dosing.
Summary The purpose of this study was to determine whether nitrate supplementation augments cutaneous reactive hyperaemia. Seven participants were tested pre‐ and postnitrate supplementation (25 ml beetroot juice); participants consumed one shot per day for 3 days. Participants were instrumented with two microdialysis fibres: control (Ringer's solution) and NO synthase inhibition (20 mM L‐ NAME ). Skin blood flow was measured via laser‐Doppler flowmetry ( LDF ). A blood pressure cuff was placed on the experimental arm and inflated to 250 mmHg for 5 mins to occlude arterial inflow. The cuff was released, and the resultant reactive hyperaemia was measured. Blood pressure was continuously measured via plethysmography from a finger on the non‐experimental arm. Cutaneous vascular conductance was calculated ( LDF / MAP ) and normalized to maximal vasodilatation (% CVC max ). Only diastolic blood pressure was reduced following nitrate supplementation (71 ± 2 vs. 66 ± 1 mmHg; P <0·05). There was no effect of nitrate supplementation on peak reactive hyperaemia at control (Pre: 52 ± 3 vs. Post: 57 ± 2% CVC max ) or L‐ NAME (Pre: 52 ± 2 vs. Post: 59 ± 4% CVC max ) sites. There was no effect of nitrate supplementation on total reactive hyperaemia at either control (Pre: 4197 ± 943 vs. Post: 4523 ± 1040% CVC max * sec) or L‐ NAME (Pre: 5108 ± 997 vs. Post: 5694 ± 1002% CVC max * sec) sites. These data suggest cutaneous reactive hyperaemia is unaffected by dietary nitrate supplementation in healthy humans.
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Wong et al. (2017) studied healthy humans (n=7). Dietary nitrate supplementation (beetroot juice) vs. Pre-supplementation baseline was evaluated on Peak cutaneous reactive hyperaemia at control sites (% CVC max). Dietary nitrate supplementation for 3 days did not significantly alter peak cutaneous reactive hyperaemia compared to baseline in healthy humans (57 vs 52 % CVC max).
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