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During endodontic retreatment of a maxillary central incisor, a midroot buccal perforation was created, and sodium hypochlorite was inadvertently forced through the perforation into surrounding tissue. The consequences of this incident included immediate severe pain and swelling, with the subsequent development of a fistula, and in the long term (15 months), paresthesia of the floor and ala of the nose and the infraorbital area.
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Reeh et al. (1989) studied this question.
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