Key result
Preprocedural NT-proBNP >32 pmol/L independently predicted all-cause mortality (HR 3.11; 95% CI 1.60-6.07; P=0.001) in patients undergoing coronary angiography over a mean follow-up of 6.7 years.
Why the study?
Does elevated preprocedural NT-proBNP predict long-term mortality and adverse cardiovascular events in patients undergoing coronary angiography for suspected CAD?
Cohort (n=337)
Does elevated preprocedural NT-proBNP predict long-term mortality and adverse cardiovascular events in patients undergoing coronary angiography for suspected CAD?
Hazard Ratio: 3.11 (95% CI 1.6–6.07)
p-value: p=0.001
Elevated preprocedural NT-proBNP (>32 pmol/L) is a strong, independent predictor of long-term mortality and adverse cardiovascular events in patients undergoing coronary angiography for suspected CAD.
May inform pre-angiography risk stratification in suspected CAD; hypothesis-generating for targeted interventions.
Recently, research interests are focussed on biomarkers to predict the outcome in patients with coronary artery disease (CAD). We examined whether the levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) could predict outcome in patients who underwent elective or acute coronary angiography (CAG). A total of 337 patients with suspected CAD who underwent elective or acute CAG were followed up for a mean period of 6.7 years. Primary end points were all-cause mortality (ACM) and the combined end point of ACM, nonfatal myocardial infarction, and revascularization. In all, 53 (16%) patients died and 88 (26%) patients reached the combined end point. Preprocedural NT-proBNP above 32 pmol/L independently predicted ACM (hazard ratio [HR] 3.11; confidence interval [CI]: 1.60-6.07; P = .001) and the combined end point (HR 2.44 [CI: 1.50-3.97]; P < .001). This study indicates that high NT-proBNP is an independent predictor of ACM on long-term follow-up. N-terminal-proBNP is a reliable predictive marker of mortality in the setting of stable or unstable angina.
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Ruwald et al. (2012) conducted a cohort in Suspected coronary artery disease (n=337). Preprocedural NT-proBNP >32 pmol/L vs. Lower NT-proBNP levels was evaluated on All-cause mortality (ACM) and the combined end point of ACM, nonfatal myocardial infarction, and revascularization (HR 3.11, 95% CI 1.60-6.07, p=0.001). Preprocedural NT-proBNP >32 pmol/L independently predicted all-cause mortality (HR 3.11; 95% CI 1.60-6.07; P=0.001) in patients undergoing coronary angiography over a mean follow-up of 6.7 years.
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