Key result
Endurance exercise training in adult zebrafish significantly increased ankrd1a expression in cardiac muscle by 6.19-fold, while ankrd1b and ankrd2 were upregulated in skeletal muscle.
Population
Zebrafish (Danio rerio) AB strain, including embryos and 8-month-old adults (n=32 for exercise experiments).
Comparison
Endurance exercise training consisting of two… vs Non-exercised control fish.
Design
Preclinical
Follow-up
3 hours after the last exercise bout
Authors
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Hypothesis-generating for ankrd1a in cardiac exercise adaptation; leaves open translation to mammalian models.
Effect estimate: 6.19 fold change
Absolute Event Rate: 6.19% vs 1%
p-value: p=<0.05
Zebrafish MARP genes are responsive to endurance exercise, establishing zebrafish as a viable in vivo model for studying cardiac and skeletal muscle stress responses.
Boskovic et al. (2018) studied Healthy (n=32). Endurance exercise training vs. Non-exercised control fish was evaluated on ankrd1a expression in cardiac muscle (6.19 fold change, p=<0.05). Endurance exercise training in adult zebrafish significantly increased ankrd1a expression in cardiac muscle by 6.19-fold, while ankrd1b and ankrd2 were upregulated in skeletal muscle.
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