Population
Mice (streptozotocin-induced diabetic and non-diabetic controls)
Comparison
Endurance training on a motor-driven treadmill… vs Sedentary controls (diabetic and non-diabetic)
Design
Preclinical
Follow-up
1, 3, or 5 weeks
Authors
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Does not support changing exercise guidelines for diabetic cardiomyopathy; hypothesis-generating for differential skeletal-cardiac titin responses.
Endurance training can alleviate diabetes-induced changes in the gene expression of titin stretch-sensing complexes in skeletal muscle, but has limited effects in cardiac muscle in a mouse model.
Lehti et al. (2006) studied this question.
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