Population
C2C12 myoblasts, C3H10T1/2 fibroblasts, and in vitro protein models
Comparison
Overexpression of wild-type MLP… vs Control cells or control expression plasmids
Design
Preclinical
Authors
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No immediate clinical implications; extends mechanistic understanding of myogenic regulation in animal models.
MLP acts as a positive developmental regulator of myogenesis by physically interacting with MyoD and enhancing its activity, revealing a novel mechanism for initiating and maintaining the myogenic program.
Kong et al. (1997) studied this question.
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