October 22, 2015Cell Death and DiseaseOpen Access

Muscle Lim Protein (MLP)/CSRP3 at the crossroad between mechanotransduction and autophagy

Q: What is the clinical evidence from this study?

Study design: Editorial. Population: Muscle cell differentiation and remodeling. Intervention: Muscle LIM protein (MLP).

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Key result

Muscle LIM protein controls myoblast differentiation and survival by regulating macroautophagy through LC3 interaction.

Design

Review

Authors

MRMamunur RashidBangladesh Council of Scientific and Industrial Research ARAlessandra RunciLeibniz Institute of Environmental Medicine MRMatteo Antonio RussoUniversità Cattolica del Sacro Cuore

Discussion

Member takes

Implication

MLP autophagy regulation may inform cardiomyopathy mechanisms; leaves open targeted validation before clinical translation.

PICO

Population

Muscle cell differentiation and remodeling

Intervention / Comparator

Muscle LIM protein (MLP)

Muscle LIM protein (MLP) plays a crucial role in muscle cytoarchitecture and differentiation, with its mutations being linked to the development of dilated and hypertrophic cardiomyopathies.

Cite This Study

Rashid et al. (2015) conducted an editorial in Muscle cell differentiation and remodeling. Muscle LIM protein (MLP) was evaluated. Muscle LIM protein (MLP) controls myoblast differentiation and survival by regulating macroautophagy through interaction with LC3.

synapsesocial.com/papers/6a0908d8bee8d5ab8a92dbe4 https://doi.org/10.1038/cddis.2015.308

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Muscle Lim Protein (MLP)/CSRP3 at the crossroad between mechanotransduction and autophagy

Discussion

Member takes

Implication

PICO

Cite This Study

Muscle Lim Protein (MLP)/CSRP3 at the crossroad between mechanotransduction and autophagy

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Also Consider