What is the clinical evidence from this study?

Study design: Other. Population: Cardiomyopathy and heart failure. Intervention: Muscle LIM protein (MLP) analysis. Primary outcome: Actin filament binding, stabilization, and bundling.

June 16, 2014Molecular and Cellular BiologyOpen Access

Human Muscle LIM Protein Dimerizes along the Actin Cytoskeleton and Cross-Links Actin Filaments

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Key result

Muscle LIM protein autonomously stabilizes and bundles actin filaments to maintain cardiomyocyte cytoarchitecture.

Authors

CHCéline HoffmannLuxembourg Institute of Health FMFlora MoreauLuxembourg Institute of Health MMMichèle MoesUniversity of Luxembourg

Discussion

Member takes

Implication

May guide cytoskeletal research in cardiomyopathy models; leaves open human translation from animal data.

PICO

Population

Cardiomyopathy and heart failure

Intervention / Comparator

Muscle LIM protein (MLP) analysis

Primary Outcome

Actin filament binding, stabilization, and bundling

Cite This Study

Hoffmann et al. (2014) studied Cardiomyopathy and heart failure. Muscle LIM protein (MLP) analysis was evaluated on Actin filament binding, stabilization, and bundling. Muscle LIM protein autonomously binds to, stabilizes, and bundles actin filaments, self-associating through its N-terminal LIM domain to maintain cardiomyocyte cytoarchitecture.

synapsesocial.com/papers/6a0cc4cd04164ea96334c2cd https://doi.org/10.1128/mcb.00651-14

Topics

Cardiomyopathy

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Human Muscle LIM Protein Dimerizes along the Actin Cytoskeleton and Cross-Links Actin Filaments

Discussion

Member takes

Implication

PICO

Cite This Study

Topics

Human Muscle LIM Protein Dimerizes along the Actin Cytoskeleton and Cross-Links Actin Filaments

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Topics

Also Consider